Official HUMIRA (adalimumab) Site
Hidradenitis suppuritiva image of HS in the armpit

POSSIBLE CAUSE OF
HIDRADENITIS SUPPURATIVA (HS)

Not an actual HS patient. HUMIRA is the first & only FDA-approved treatment for moderate to severe hidradenitis suppuritiva

HS is believed to be caused by systemic inflammation, driven by proinflammatory cytokines such as TNF-α (tumor necrosis factor-alpha).2,3

Overexpression of TNF-α plays a key role in fueling HS inflammation.1,4 In one study, HS lesions expressed 5 times more TNF-α than normal skin.4

1 Hair follicles become plugged with keratin, then rupture, leaking contents into connective tissue5,6
2 An inflammatory response follows, fueled by TNF-α and other proinflammatory cytokines, and an inflammatory nodule or abscess forms3,6

TNF-α=tumor necrosis factor-alpha. Adapted with permission from van der Zee, 2012.6

3 The wound heals, but the process becomes chronic, which may lead to sinus tracts and hypertrophic scars5

HS is in the axillae

Adapted with permission from Jemec, 2012.7

As shown in the illustration above, follicular plugging in patients’ sensitive areas can lead to excess keratinocyte production and eventual ductal rupture, stimulating an immune system response. This cycle of TNF-α inflammatory response eventually becomes chronic.6

TNF-α PLAYS A ROLE IN MANY CHRONIC, IMMUNE-MEDIATED CONDITIONS1,4,8

TNF-a plays a role in rheumatology: RA, PsA, AS, JIA, UV

RHEUMATOLOGY1

Psoriatic arthritis

Rheumatoid arthritis

Ankylosing spondylitis

Juvenile idiopathic arthritis

Uveitis

TNF-a plays a role in gastroenterology: UC, CD, PEDs CD

GASTROENTEROLOGY1

Ulcerative colitis

Adult Crohn’s disease

Pediatric Crohn’s disease

TNF-a plays a role in dermatology: Ps, PsA, HS

DERMATOLOGY1

Plaque psoriasis

Psoriatic arthritis

Hidradenitis suppurativa

TNF-a plays a role in ophthamology: uveitis

OPHTHALMOLOGY1

Uveitis

FIND A DERMATOLOGIST
FOR A REFERRAL

“I refer my moderate to severe patients to a dermatologist. My relationship as an OB/GYN stays the same, so the dermatologist and I partner in the treatment of HS patients.”

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Terms and Conditions

AbbVie is providing this service to help patients find dermatologists in their area who have experience with HUMIRA.

No fees have been received by or paid to dermatologists for inclusion in this specialist locator directory. Inclusion of a physician in this directory does not represent an endorsement by or a recommendation from AbbVie Inc., nor does it imply that the dermatologists on the list will determine if HUMIRA is right for you.

The selection of a physician is an important decision that should not be based solely on the inclusion in this dermatologist locator tool.

AbbVie Inc. is a maker and marketer of HUMIRA (adalimumab).